Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Epstein-Barr Virus Immediate-Early Protein BZLF1 Regulates p53 Function through Multiple Mechanisms

18 Nov 2002

Abstract excerpt

The Epstein-Barr virus (EBV) immediate-early protein BZLF1 is a transcriptional activator that mediates the switch between the latent and the lytic forms of EBV infection. It was previously reported that BZLF1 inhibits p53 transcriptional function in reporter gene assays. Here we further examined the effects of BZLF1 on p53 function by using a BZLF1-expressing adenovirus vector (AdBZLF1). Infection of cells with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to RNA modifications and cancer
Share to Viral-associated cancers and disorders

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12438576
DOI: 10.1128/jvi.76.24.12503-12512.2002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Epstein-Barr Virus Immediate-Early Protein BZLF1 Regulates p53 Function through Multiple MechanismsPMID 12438576Read ↗

Expression of Epstein–Barr virus BZLF1 immediate-early protein induces p53 degradation independent of MDM2, leading to repression of p53-mediated transcriptionSemantic proximity Read ↗

Transient increases in p53-responsible gene expression at early stages of Epstein-Barr virus productive replicationSemantic proximity Read ↗

Functional and Physical Interaction between p53 and BZLF1: Implications for Epstein-Barr Virus LatencySemantic proximity Read ↗

Functional and physical interaction between p53 and BZLF1: implications for Epstein-Barr virus latency.Semantic proximity Read ↗

Structure and function of the Epstein-Barr virus BZLF1 protein.Semantic proximity Read ↗

Epstein–Barr virus BZLF1 protein impairs accumulation of host DNA damage proteins at damage sites in response to DNA damageSemantic proximity Read ↗

Functional Interaction between Epstein-Barr Virus Replication Protein Zta and Host DNA Damage Response Protein 53BP1Semantic proximity Read ↗

Transcriptional repression by sumoylation of Epstein-Barr virus BZLF1 protein correlates with association of histone deacetylase.Semantic proximity Read ↗

Critical Role of p53 in Histone Deacetylase Inhibitor-Induced Epstein-Barr Virus Zta ExpressionSemantic proximity Read ↗

Epigenetic modification of the Epstein-Barr virus BZLF1 promoter regulates viral reactivation from latencySemantic proximity Read ↗

Transcription of the Epstein–Barr Virus Lytic Cycle Activator BZLF-1 During Oxidative Stress InductionSemantic proximity Read ↗

Characterization of the Epstein-Barr virus BZLF1 protein transactivation domainSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.