Article

A Negative Regulatory Element in the <i>bcl-2</i> 5'-Untranslated Region Inhibits Expression from an Upstream Promoter

1993-06-01

Abstract excerpt

bcl-2 mRNA is present at high levels in pre-B-cell lines but is down-regulated in most mature B-cell lines. To investigate the mechanisms responsible for its developmental control, we studied the regulation of bcl-2 expression in human B-lineage cell lines. Using nuclear run-on assays, we found that bcl-2 transcription decreases in parallel with levels of steady-state mRNA during B-cell development. To define cis-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9420b66b-0709-53f9-bc43-046744353f3e
DOI: 10.1128/mcb.13.6.3686-3697.1993

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Negative Regulatory Element in the <i>bcl-2</i> 5'-Untranslated Region Inhibits Expression from an Upstream PromoterDOI 10.1128/mcb.13.6.3686-3697.1993Read

A negative regulatory element in the bcl-2 5'-untranslated region inhibits expression from an upstream promoter.Semantic proximity Read

Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x geneSemantic proximity Read

Transcriptional regulation of the BCL-6 gene: mechanistic dissection using mutant cell lines.Semantic proximity Read

Cytoplasmic mutant p53 increases Bcl-2 expression in estrogen receptor-positive breast cancer cells.Semantic proximity Read

The WT1 protein is a negative regulator of the normal bcl-2 allele in t(14;18) lymphomas.Semantic proximity Read

Heterogeneous Nuclear Ribonucleoprotein F/H Proteins Modulate the Alternative Splicing of the Apoptotic Mediator Bcl-xSemantic proximity Read

A minimal Bcl-x promoter is activated by Brn-3a and repressed by p53.Semantic proximity Read

Negative and positive cis-acting elements control the expression of murine alpha 1-protease inhibitor genes.Semantic proximity Read

Ets-2 Repressor Factor (ERF) mediates repression of the human cytomegalovirus major immediate-early promoter in undifferentiated non-permissive cellsSemantic proximity Read

Epstein-Barr Virus BALF1 Is a BCL-2-Like Antagonist of the Herpesvirus Antiapoptotic BCL-2 ProteinsSemantic proximity Read

A negative regulatory element and its binding protein in the upstream of enhancer II of hepatitis B virus.Semantic proximity Read

Identification of a negative Cis-regulatory element and multiple DNA binding proteins that inhibit transcription of the transforming growth factor-beta type II receptor gene.Semantic proximity Read