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Article

Association of a novel regulatory polymorphism (-938C>A) in the BCL2 gene promoter with disease progression and survival in chronic lymphocytic leukemia.

Blood - 1 Jan 2007

Nückel Holger, Frey Ulrich H, Bau Maja, Sellmann Ludger, Stanelle Jens, Dürig Jan, Jöckel Karl-Heinz, Dührsen Ulrich, Siffert Winfried

Abstract excerpt

Bcl-2 plays a key role in the regulation of apoptosis. We investigated the role of a novel regulatory single-nucleotide polymorphism (-938C>A) in the inhibitory P2 BCL2 promoter in B-cell chronic lymphocytic leukemia (B-CLL). The -938C allele displayed significantly increased BCL2 promoter activity and binding of nuclear proteins compared with the A allele. Concomitantly, Bcl-2 protein expression in B cells from...

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Identifiers

PMID: 16960146
DOI: 10.1182/blood-2006-03-007567

Genes

BCL2

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Research trail→

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Association of a novel regulatory polymorphism (-938C>A) in the BCL2 gene promoter with disease progression and survival in chronic lymphocytic leukemia.PMID 16960146Read ↗

The BCL-2 promoter (-938C>A) polymorphism does not predict clinical outcome in chronic lymphocytic leukemia.Semantic proximity Read ↗

BCL2 expression in chronic lymphocytic leukemia: lack of association with the BCL2 938A>C promoter single nucleotide polymorphism.Semantic proximity Read ↗

Influence of BCL2-938 C>A promoter polymorphism and BCL2 gene expression on the progression of breast cancer.Semantic proximity Read ↗

Association of the AA genotype of the BCL2 (-938C>A) promoter polymorphism with better survival in ovarian cancer.Semantic proximity Read ↗

The AA genotype of the regulatory BCL2 promoter polymorphism ( 938C>A) is associated with a favorable outcome in lymph node negative invasive breast cancer patients.Semantic proximity Read ↗

BCL2-938C>A polymorphism and disease progression in chronic lymphocytic leukemia.Semantic proximity Read ↗

The bcl2 -938CC genotype has poor prognosis and lower survival in renal cancer.Semantic proximity Read ↗

The regulatory BCL2 promoter polymorphism (-938C>A) is associated with relapse and survival of patients with oropharyngeal squamous cell carcinoma.Semantic proximity Read ↗

Association of the CC genotype of the regulatory BCL2 promoter polymorphism (-938C>A) with better 2-year survival in patients with glioblastoma multiforme.Semantic proximity Read ↗

Role of Bcl-2 -938 C>A polymorphism in susceptibility and prognosis of cancer: a meta-analysis.Semantic proximity Read ↗

BCL-2 (-938C > A) polymorphism is associated with breast cancer susceptibility.Semantic proximity Read ↗

Regulatory BCL2 promoter polymorphism (-938C>A) is associated with adverse outcome in patients with prostate carcinoma.Semantic proximity Read ↗

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