Article
The bcl-2 gene and protein in malignant lymphomas.
Bulletin du cancer - 1 Jan 1991
Cleary M L
Abstract excerpt
The 14;18 chromosomal translocation, characteristic of a significant fraction of non-Hodgkin's lymphomas, results from an apparent error in immunoglobulin gene rearrangement. Breakpoints for the 14;18 translocation cluster at defined sites on chromosomes 14 and 18 and this clustering has important implications for molecular diagnostic studies of lymphomas. The major effect of the 14;18 translocation is a...
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