The bcl-2 gene and protein in malignant lymphomas.

Article

The bcl-2 gene and protein in malignant lymphomas.

Bulletin du cancer - 1 Jan 1991

Cleary M L

Abstract excerpt

The 14;18 chromosomal translocation, characteristic of a significant fraction of non-Hodgkin's lymphomas, results from an apparent error in immunoglobulin gene rearrangement. Breakpoints for the 14;18 translocation cluster at defined sites on chromosomes 14 and 18 and this clustering has importan...

Topics

Animals
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 18
GTP-Binding Proteins
Gene Expression Regulation, Neoplastic
Humans
Lymphoma, Non-Hodgkin
Phenotype
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
Translocation, Genetic

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