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Article

HSP70 Binding Sites in the Tumor Suppressor Protein p53

1 Aug 1997

Abstract excerpt

Mutations within conserved regions of the tumor suppressor protein, p53, result in oncogenic forms of the protein with altered tertiary structures. In most cases, the mutant p53 proteins are selectively recognized and bound by members of the HSP70 family of molecular chaperones, but the binding site(s) in p53 for these chaperones have not been clearly defined. We have screened a library of overlapping...

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PMID: 9235949
DOI: 10.1074/jbc.272.31.19471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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HSP70 Binding Sites in the Tumor Suppressor Protein p53PMID 9235949Read ↗

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Interaction between hsp70 and hsp40, eukaryotic homologues of DnaK and DnaJ, in human cells expressing mutant-type p53.Semantic proximity Read ↗

Hsp70 family member, mot-2/mthsp70/GRP75, binds to the cytoplasmic sequestration domain of the p53 protein.Semantic proximity Read ↗

Activation of the cryptic DNA binding function of mutant forms of p53.Semantic proximity Read ↗

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