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Article

Chaperone-dependent stabilization and degradation of p53 mutants.

Oncogene - 29 May 2008

Muller P, Hrstka R, Coomber D, Lane D P, Vojtesek B

Abstract excerpt

p53 missense mutant proteins commonly show increased stability compared to wild-type p53, which is thought to depend largely on the inability of mutant p53 to induce the ubiquitin ligase MDM2. However, recent work using mouse models has shown that the accumulation of mutant p53 occurs only in tumour cells, indicating that stabilization requires additional factors. To clarify the stabilization of p53 mutants in...

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Source

Identifiers

PMID: 18223694
DOI: 10.1038/sj.onc.1211010

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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