Article
Dominant-negative p53 mutations selected in yeast hit cancer hot spots.
Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 1996
Brachmann R K, Vidal M, Boeke J D
Abstract excerpt
Clinically important mutant p53 proteins may be tumorigenic through a dominant-negative mechanism or due to a gain-of-function. Examples for both hypotheses have been described; however, it remains unclear to what extent they apply to TP53 mutations in general. Here it is shown that the mutationa...
Topics
- Amino Acid Sequence
- Base Sequence
- Blotting, Western
- Cloning, Molecular
- Codon
- Genes, Dominant
- Genes, p53
- Genotype
- Humans
- Molecular Sequence Data
- Neoplasms
- Phenotype
- Plasmids
- Point Mutation
- Saccharomyces cerevisiae
- Tumor Suppressor Protein p53