Article
Dominant-negative p53 mutations selected in yeast hit cancer hot spots.
Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 1996
Brachmann R K, Vidal M, Boeke J D
Abstract excerpt
Clinically important mutant p53 proteins may be tumorigenic through a dominant-negative mechanism or due to a gain-of-function. Examples for both hypotheses have been described; however, it remains unclear to what extent they apply to TP53 mutations in general. Here it is shown that the mutational spectrum of dominant-negative p53 mutants selected in a novel yeast assay correlates tightly with p53 mutations in...
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