Modulation of the epidermal growth factor mitogenic response by metabolites of linoleic and arachidonic acid in Syrian hamster embryo fibroblasts. Differential effects in tumor suppressor gene (+) and (-) phenotypes.

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Article

Modulation of the epidermal growth factor mitogenic response by metabolites of linoleic and arachidonic acid in Syrian hamster embryo fibroblasts. Differential effects in tumor suppressor gene (+) and (-) phenotypes.

The Journal of biological chemistry - 25 May 1992

Glasgow W C, Afshari C A, Barrett J C, Eling T E

Abstract excerpt

Specific metabolites of arachidonic and linoleic acid have been proposed as serving a regulatory function in growth factor signal transduction in fibroblasts. In studies with Syrian hamster embryo (SHE) fibroblasts, we found lipoxygenase inhibitors to be potent blockers of epidermal growth factor...

Topics

Animals
Arachidonic Acid
Autoradiography
Chromatography, High Pressure Liquid
Cricetinae
DNA
Dinoprost
Dinoprostone
Epidermal Growth Factor
Fibroblasts
Gas Chromatography-Mass Spectrometry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Tumor Suppressor

Linoleic Acid

Linoleic Acids

Lipoxygenase Inhibitors

Mesocricetus

Mitogens

Phenotype

Source

Open in PubMed

Identifiers

PMID: 1587852

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1587852-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Modulation of the epidermal growth factor mitogenic response by metabolites of linoleic and arachidonic acid in Syrian hamster embryo fibroblasts. Differential effects in tumor suppressor gene (+) and (-) phenotypes.PMID 1587852Read ↗

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