Article
The linoleic acid metabolite, 13-HpODE augments the phosphorylation of EGF receptor and SHP-2 leading to their increased association.
Prostaglandins, leukotrienes, and essential fatty acids - 1 Aug 1999
Hui R, Kameda H, Risinger J I, Angerman-Stewart J, Han B, Barrett J C, Eling T E, Glasgow W C
Abstract excerpt
In previous studies with Syrian hamster embryo fibroblasts, we found that a specific lipoxygenase metabolite of linoleic acid, 13(S)-hydroperoxyoctadecadienoic acid (HpODE), enhanced epidermal growth factor (EGF) signal transduction in a tumor suppressor gene plus phenotype (supB+); with a diminished response to 13(S)-HpODE in a tumor suppressor gene minus phenotype (supB-). This differential response was...
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