Article
Epidermal growth factor-stimulated production of esterified 13(S)-hydroxyoctadecadienoic acid is associated with tumor suppressor phenotype in Syrian hamster embryo fibroblasts.
Journal of lipid research - 1 Jan 1997
Hui R, Everhart A L, Glasgow W C
Abstract excerpt
Epidermal growth factor (EGF) stimulates the lipoxygenase metabolism of linoleic acid to 13(S)-hydroxyoctadecadienoic acid (HODE) in Syrian hamster embryo (SHE) fibroblasts. 13(S)-HODE is a potent and specific enhancer of EGF-dependent DNA synthesis in normal phenotypic SHE cells (supB+), but is...
Topics
- Animals
- Cell Line
- Chemical Fractionation
- Cricetinae
- Embryo, Mammalian
- Epidermal Growth Factor
- Esterification
- Fibroblasts
- Genes, Tumor Suppressor
- Linoleic Acids
- Lipids
- Mesocricetus
- Phenotype
- Phospholipids
- Protein-Tyrosine Kinases
- Stimulation, Chemical