Article
Glutathione S-transferase class mu deletion polymorphism and breast cancer: results from prevalent versus incident cases.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 1997
Kelsey K T, Hankinson S E, Colditz G A, Springer K, Garcia-Closas M, Spiegelman D, Manson J E, Garland M, Stampfer M J, Willett W C, Speizer F E, Hunter D J
Abstract excerpt
A common deletion polymorphism in the gene coding for the glutathione S-transferase class mu (the GSTM1 gene) results in a decreased ability to detoxify carcinogenic epoxide intermediates and has been associated with increased breast cancer risk in some small studies. We studied the GSTM1 gene deletion polymorphism (conferring the null genotype) in 243 women who had prevalent breast cancer and 245 women without...
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