Article
Polymorphism of glutathione S-transferase M1 and lung cancer risk among African-Americans and Caucasians in Los Angeles County, California.
Journal of the National Cancer Institute - 16 Aug 1995
London S J, Daly A K, Cooper J, Navidi W C, Carpenter C L, Idle J R
Abstract excerpt
BACKGROUND: Glutathione S-transferase M1 (GSTM1) is active in the detoxication of a number of carcinogens, including polyaromatic hydrocarbons, such as those present in cigarette smoke. In about 30%-55% of individuals, depending on the ethnic group, there is a virtual absence of GSTM1 enzyme acti...
Topics
- Aged
- Antioxidants
- Asbestos
- Black People
- California
- Case-Control Studies
- Environmental Exposure
- Female
- Genotype
- Glutathione Transferase
- Humans
- Lung Neoplasms
- Male
- Middle Aged
- Odds Ratio
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Risk Factors