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Article

Association of homozygous wild-type glutathione S-transferase M1 genotype with increased breast cancer risk.

Cancer research - 15 Feb 2004

Roodi Nady, Dupont William D, Moore Jason H, Parl Fritz F

Abstract excerpt

More than 500 studies have examined the association of the glutathione S-transferase M1 (GSTM1) genotype with various malignancies yielding inconsistent results. The genotyping was based on a PCR assay that identified the GSTM1 null (-/-) genotype but did not distinguish homozygous wild-type (+/+) and heterozygous (+/-) individuals. We developed an assay that allowed the definition of +/+, +/-, and -/- genotypes...

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Source

Identifiers

PMID: 14973116
DOI: 10.1158/0008-5472.can-03-2861

Genes

GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of homozygous wild-type glutathione S-transferase M1 genotype with increased breast cancer risk.PMID 14973116Read ↗

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A functional polymorphism in the promoter region of GSTM1 implies a complex role for GSTM1 in breast cancer.Semantic proximity Read ↗

Glutathione S-transferase M1, T1, and P1 genotypes and breast cancer risk: a study in a Portuguese population.Semantic proximity Read ↗

Glutathione S-transferase M1 Polymorphism and Breast Cancer Risk: a Meta-Analysis in the Chinese Population.Semantic proximity Read ↗

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Glutathione S-transferase T1 polymorphism is associated with breast cancer susceptibility.Semantic proximity Read ↗

Evaluation of molecular markers GSTM1 and GSTT1 and clinical factors in breast cancer: case-control study and literature review.Semantic proximity Read ↗

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Worldwide Systematic Review of GSTM1 and GSTT1 Null Genotypes by Continent, Ethnicity, and Therapeutic Area.Semantic proximity Read ↗

High-throughput genotyping method for glutathione S-transferase T1 and M1 gene deletions using TaqMan probes.Semantic proximity Read ↗

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