Article
Pooled analysis indicates that the GSTT1 deletion, GSTM1 deletion, and GSTP1 Ile105Val polymorphisms do not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers.
Breast cancer research and treatment - 1 Jul 2010
Spurdle Amanda B, Fahey Paul, Chen Xiaoqing, McGuffog Lesley, Easton Douglas, Peock Susan, Cook Margaret, Simard Jacques, Rebbeck Tim R, Antoniou Antonis C, Chenevix-Trench Georgia
Abstract excerpt
The GSTP1, GSTM1, and GSTT1 detoxification genes all have functional polymorphisms that are common in the general population. A single study of 320 BRCA1/2 carriers previously assessed their effect in BRCA1 or BRCA2 mutation carriers. This study showed no evidence for altered risk of breast cancer for individuals with the GSTT1 and GSTM1 deletion variants, but did report that the GSTP1 Ile105Val (rs1695) variant...
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