Article
Genetic control of blood pressure and the angiotensinogen locus.
Proceedings of the National Academy of Sciences of the United States of America - 28 Mar 1995
Kim H S, Krege J H, Kluckman K D, Hagaman J R, Hodgin J B, Best C F, Jennette J C, Coffman T M, Maeda N, Smithies O
Abstract excerpt
Variants of the human angiotensinogen gene have been linked in some studies to increased circulating angiotensinogen levels and essential hypertension. To test for direct causality between genotypes at the angiotensinogen locus and blood pressures, we have studied mice carrying zero, one, two, three, or four functional copies of the murine wild-type angiotensinogen gene (Agt) at its normal chromosomal location....
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