Article
An in vivo characterization of the cleavage site specificity of the insulin cell prohormone processing enzymes.
The Journal of biological chemistry - 25 May 1990
Thorne B A, Thomas G
Abstract excerpt
Most peptide hormones and neurotransmitters are synthesized as larger precursor proteins, which are post-translationally processed to mature bioactive products. An early event in prohormone maturation is endoproteolytic cleavage, occurring usually at pairs of basic amino acids (e.g. Lys-Arg). Sin...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Cell Line
- Codon
- Endopeptidases
- Insulinoma
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Pancreatic Neoplasms