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Article

Behavior in the eukaryotic secretory pathway of insulin-containing fusion proteins and single-chain insulins bearing various B-chain mutations.

The Journal of biological chemistry - 7 Feb 2003

Zhang Bao-yan, Liu Ming, Arvan Peter

Abstract excerpt

In the secretory pathway, endoproteolytic cleavage of the insulin precursor protein promotes a change in the biophysical properties of the processed insulin product, and this may be relevant for its intracellular trafficking. We have now studied several independent point mutants contained within the insulin B-chain, S9D, H10D, V12E (called B9D, B10D, and B12E), as well as the double point mutant P28K,K29P...

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PMID: 12446709
DOI: 10.1074/jbc.M209474200

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