Identification of residues in the insulin molecule important for binding to insulin-degrading enzyme.

doi:10.1021/bi00485a022

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Article

Identification of residues in the insulin molecule important for binding to insulin-degrading enzyme.

Biochemistry - 21 Aug 1990

Affholter J A, Cascieri M A, Bayne M L, Brange J, Casaretto M, Roth R A

Abstract excerpt

Insulin-degrading enzyme (IDE) hydrolyzes insulin at a limited number of sites. Although the positions of these cleavages are known, the residues of insulin important in its binding to IDE have not been defined. To this end, we have studied the binding of a variety of insulin analogues to the pro...

Topics

Animals
Erythrocytes
Humans
Hydrogen
Insulin
Insulin-Like Growth Factor I
Insulysin
Mutation
Peptide Hydrolases
Protein Conformation
Receptor, Insulin
Swine

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