Article
P53, cell cycle control and apoptosis: implications for cancer.
Cancer metastasis reviews - 1 Mar 1995
Kastan M B, Canman C E, Leonard C J
Abstract excerpt
Cellular proliferation depends on the rates of both cell division and cell death. Tumors frequently have decreased cell death as a primary mode of increased cell proliferation. Genetic changes resulting in loss of programmed cell death (apoptosis) are likely to be critical components of tumorigenesis. Many of the gene products which appear to control apoptotic tendencies are regulators of cell cycle progression;...
Topics
- Apoptosis
- Cell Cycle
- Cell Cycle Proteins
- Cell Survival
- Cell Transformation, Neoplastic
- DNA Damage
- G1 Phase
- Gene Expression Regulation
- Genes, p53
- Humans
- Mutation
- Neoplasms