Article
Restoration of p53 function for selective Fas-mediated apoptosis in human and rat glioma cells in vitro and in vivo by a p53 COOH-terminal peptide.
Molecular cancer therapeutics - 1 Jan 2006
Senatus Patrick B, Li Yin, Mandigo Christopher, Nichols Gwen, Moise Gaetan, Mao Yuehua, Brown Melandee D, Anderson Richard C, Parsa Andrew T, Brandt-Rauf Paul W, Bruce Jeffrey N, Fine Robert L
Abstract excerpt
We have shown that a COOH-terminal peptide of p53 (amino acids 361-382, p53p), linked to the truncated homeobox domain of Antennapedia (Ant) as a carrier for transduction, induced rapid apoptosis in human premalignant and malignant cell lines. Here, we report that human and rat glioma lines containing endogenous mutant p53 or wild-type (WT) p53 were induced into apoptosis by exposure to this peptide called...
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