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Article

Overexpression of ATase1 and ATase2 disrupts the secretome and causes a progeria phenotype.

Life science alliance - 1 Dec 2025

Cheng Tzu-Lin, Wu Feixuan, Haque Md Ezazul, Thiel Abigail R, Wang Danqing, Helgager Jeffrey J, Li Lingjun, Puglielli Luigi

Abstract excerpt

Nε-lysine acetylation in the lumen of the ER requires two acetyltransferases, ATase1/NAT8B and ATase2/NAT8. They are type II membrane proteins and belong to the larger GNAT superfamily of acetyltransferases. Their enzymatic activity is tightly coupled to the import of acetyl-CoA in the lumen of the ER by AT-1/SLC33A1. Gene duplication events involving 3q25.31 (harboring AT-1/SLC33A1) and 2p13.1 (harboring...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40930841
DOI: 10.26508/lsa.202503378
PMCID: PMC12423556

Genes

NAT8
SLC33A1

Provenance

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