Article
Suppression of autocrine cell proliferation and tumorigenesis of human melanoma cells and fibroblast growth factor transformed fibroblasts by a kinase-deficient FGF receptor 1: evidence for the involvement of Src-family kinases.
Oncogene - 26 Jun 1997
Yayon A, Ma Y S, Safran M, Klagsbrun M, Halaban R
Abstract excerpt
Basic Fibroblast Growth Factor (bFGF/FGF2) is thought to play a decisive role in malignant progression. Aberrant expression of bFGF causes constitutive autocrine activation of its cognate receptor and autonomous growth of human melanoma cells or bFGF transformed fibroblasts in culture. It remains...
Topics
- 3T3 Cells
- Animals
- Cell Division
- Cell Line, Transformed
- Fibroblast Growth Factor 2
- Fibroblasts
- Filaggrin Proteins
- Genes, Dominant
- Humans
- Melanoma
- Mice
- Phenotype
- Protein-Tyrosine Kinases
- Receptor Protein-Tyrosine Kinases