Fibroblast growth factor receptor-mediated signals contribute to the malignant phenotype of non-small cell lung cancer cells: therapeutic implications and synergism with epidermal growth factor receptor inhibition.

doi:10.1158/1535-7163.MCT-08-0444

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Fibroblast growth factor receptor-mediated signals contribute to the malignant phenotype of non-small cell lung cancer cells: therapeutic implications and synergism with epidermal growth factor receptor inhibition.

Molecular cancer therapeutics - 1 Oct 2008

Fischer Hendrik, Taylor Ninon, Allerstorfer Sigrid, Grusch Michael, Sonvilla Gudrun, Holzmann Klaus, Setinek Ulrike, Elbling Leonilla, Cantonati Heidelinde, Grasl-Kraupp Bettina, Gauglhofer Christine, Marian Brigitte, Micksche Michael, Berger Walter

Abstract excerpt

Fibroblast growth factors (FGF) and their high-affinity receptors (FGFR) represent an extensive cellular growth and survival system. Aim of this study was to evaluate the contribution of FGF/FGFR-mediated signals to the malignant growth of non-small cell lung cancer (NSCLC) and to assess their potential as targets for therapeutic interventions. Multiple FGFR mRNA splice variants were coexpressed in NSCLC cells (n...

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PMID: 18852144
DOI: 10.1158/1535-7163.MCT-08-0444
PMCID: PMC2879863

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FGFR1

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