Article
Inhibition of fibroblast growth factor/fibroblast growth factor receptor activity in glioma cells impedes tumor growth by both angiogenesis-dependent and -independent mechanisms.
Cancer research - 15 Feb 2001
Auguste P, Gürsel D B, Lemière S, Reimers D, Cuevas P, Carceller F, Di Santo J P, Bikfalvi A
Abstract excerpt
We undertook a series of systematic studies to address the role of fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) activity in tumor growth and angiogenesis. We expressed dominant-negative FGFR2 (FGFR2-DN) or FGFR1 (FGFR1-DN) in glioma C6 cells by using constitutive or tetra...
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