Molecular correlates in the progression of normal melanocytes to melanomas.

Abstract excerpt

The malignant phenotype of melanocytes in vitro is characterized by growth factor autonomy, refractory to inhibitors and loss of differentiated functions. The molecular basis for these changes is not yet fully understood but it is likely to involve the inappropriate expression of specific genes t...

Topics

• Cell Transformation, Neoplastic
• Humans
• Melanocytes
• Melanoma
• Neoplasms, Radiation-Induced
• Phenotype