Article
Basic fibroblast growth factor induces a transformed phenotype in normal human melanocytes.
Oncogene - 11 Nov 1999
Nesbit M, Nesbit H K, Bennett J, Andl T, Hsu M Y, Dejesus E, McBrian M, Gupta A R, Eck S L, Herlyn M
Abstract excerpt
Basic fibroblast growth factor (bFGF or FGF-2) is produced by nearly all melanomas in vitro and in vivo but not by normal melanocytes, which require exogenous bFGF for growth. In this study, we transduced normal human melanocytes to overexpress two forms of bFGF: (bFGF-Long and bFGF-Short) using replication-deficient adenovirus 5 vectors. bFGF-Long induced the 17.8, 22.5, 23.1 and 24.2 kDa forms of bFGF, whereas...
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