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Article

Dilute passage promotes expression of genetic and phenotypic variants of human immunodeficiency virus type 1 in cell culture.

Journal of virology - 1 May 1993

Sánchez-Palomino S, Rojas J M, Martínez M A, Fenyö E M, Nájera R, Domingo E, López-Galíndez C

Abstract excerpt

We have studied the extent of genetic and phenotypic diversification of human immunodeficiency virus type 1 (HIV-1) upon 15 serial passages of clonal viral populations in MT-4 cell cultures. Several genetic and phenotypic modifications previously noted during evolution of HIV-1 in infected humans were also observed upon passages of the virus in cell culture. Notably, the transition from non-syncytium-inducing to...

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Identifiers

PMID: 8474182
DOI: 10.1128/JVI.67.5.2938-2943.1993
PMCID: PMC237623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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