Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic heterogeneity in a panel of infectious molecular human immunodeficiency virus type 1 clones derived from a single individual.

Journal of virology - 1 Apr 1991

Groenink M, Fouchier R A, de Goede R E, de Wolf F, Gruters R A, Cuypers H T, Huisman H G, Tersmette M

Abstract excerpt

Previously, we and others have demonstrated a relation between the clinical course of human immunodeficiency virus type 1 (HIV-1) infection and biological properties of HIV-1 variants such as replication rate, syncytium-inducing (SI) capacity, and cytotropism. For the molecular analysis of the biological variability in these properties, we generated a panel of phenotypically distinct yet genetically highly...

Topics

Acquired Immunodeficiency Syndrome
Amino Acid Sequence
Base Sequence
Cell Line
Cloning, Molecular
Genes, tat
Genetic Variation
Giant Cells
HIV-1
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Restriction Mapping

Sequence Homology, Nucleic Acid

T-Lymphocytes

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 2002552
DOI: 10.1128/JVI.65.4.1968-1975.1991
PMCID: PMC240031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2002552-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic heterogeneity in a panel of infectious molecular human immunodeficiency virus type 1 clones derived from a single individual.PMID 2002552Read ↗

[Expression of different HIV-1 phenotypic subpopulations through the natural history of the infection].Semantic proximity Read ↗

Prototypical Recombinant Multi-Protease-Inhibitor-Resistant Infectious Molecular Clones of Human Immunodeficiency Virus Type 1Semantic proximity Read ↗

An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic strain of human immunodeficiency virus type 1Semantic proximity Read ↗

Viral determinants of human immunodeficiency virus type 1 T-cell or macrophage tropism, cytopathogenicity, and CD4 antigen modulationSemantic proximity Read ↗

Monocytotropic human immunodeficiency virus type 1 (HIV-1) variants detectable in all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture.Semantic proximity Read ↗

Evolution of syncytium-inducing and non-syncytium-inducing biological virus clones in relation to replication kinetics during the course of human immunodeficiency virus type 1 infection.Semantic proximity Read ↗

Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus populationSemantic proximity Read ↗

Evidence for differences in MT2 cell tropism according to genetic subtypes of HIV-1: syncytium-inducing variants seem rare among subtype C HIV-1 viruses.Semantic proximity Read ↗

Biological properties of HIV isolates in primary HIV infection: consequences for the subsequent course of infection.Semantic proximity Read ↗

HIV-1 evolves into a nonsyncytium-inducing virus upon prolonged culture in vitro.Semantic proximity Read ↗

HIV-1 biological phenotype in long-term infected individuals evaluated with an MT-2 cocultivation assay.Semantic proximity Read ↗

Five human immunodeficiency virus type 1 phenotypic variants with different MT-2 cell tropisms correlate with prognostic markers of disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.