Article
Enhanced closed-state inactivation in a mutant Shaker K+ channel.
The Journal of membrane biology - 1 Jun 1997
Ayer R K, Sigworth F J
Abstract excerpt
Many mutations that shift the voltage dependence of activation in Shaker channels cause a parallel shift of inactivation. The I2 mutation (L382I in the Shaker B sequence) is an exception, causing a 45 mV activation shift with only a 9 mV shift of inactivation midpoint relative to the wildtype (WT...
Topics
- Animals
- Drosophila
- Drosophila Proteins
- Ion Channel Gating
- Mutation
- Patch-Clamp Techniques
- Potassium Channels
- Shaker Superfamily of Potassium Channels
- Xenopus