Article
Macroscopic Na+ currents in the "Nonconducting" Shaker potassium channel mutant W434F.
The Journal of general physiology - 1 Jul 1998
Starkus J G, Kuschel L, Rayner M D, Heinemann S H
Abstract excerpt
C-type inactivation in Shaker potassium channels inhibits K+ permeation. The associated structural changes appear to involve the outer region of the pore. Recently, we have shown that C-type inactivation involves a change in the selectivity of the Shaker channel, such that C-type inactivated chan...
Topics
- Animals
- Ion Channel Gating
- Kinetics
- Mutation
- Oocytes
- Patch-Clamp Techniques
- Potassium
- Potassium Channels
- Shaker Superfamily of Potassium Channels
- Sodium
- Xenopus laevis