Article
Frequent mutation in pX region of HTLV-1 is observed in HAM/TSP patients, but is not specifically associated with the central nervous system lesions.
Journal of neurovirology - 1 Sept 1995
Saito M, Furukawa Y, Kubota R, Usuku K, Sonoda S, Izumo S, Osame M, Yoshida M
Abstract excerpt
Human T-cell leukemia virus type 1 (HTLV-1) is an etiologic agent of adult T-cell leukemia (ATL) and of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Recently it has been reported that defective HTLV-1 provirus was detected frequently in the central nervous system (CNS) les...
Topics
- Adult
- Aged
- Amino Acid Sequence
- Blotting, Southern
- Carrier State
- Central Nervous System
- DNA Mutational Analysis
- Female
- Genes, Viral
- Human T-lymphotropic virus 1
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Paraparesis, Tropical Spastic