Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Frequent mutation in pX region of HTLV-1 is observed in HAM/TSP patients, but is not specifically associated with the central nervous system lesions.

Journal of neurovirology - 1 Sept 1995

Saito M, Furukawa Y, Kubota R, Usuku K, Sonoda S, Izumo S, Osame M, Yoshida M

Abstract excerpt

Human T-cell leukemia virus type 1 (HTLV-1) is an etiologic agent of adult T-cell leukemia (ATL) and of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Recently it has been reported that defective HTLV-1 provirus was detected frequently in the central nervous system (CNS) lesions of HAM/TSP patients. Here we investigated sequence variations of the pX region of HTLV-1 in the CNS and peripheral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Amino Acid Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Blotting, Southern

Share to Central Nervous System

Share to DNA Mutational Analysis

Share to Genes, Viral

Share to Molecular Sequence Data

Share to Mutation

Source

Identifiers

PMID: 9222367
DOI: 10.3109/13550289509114025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequent mutation in pX region of HTLV-1 is observed in HAM/TSP patients, but is not specifically associated with the central nervous system lesions.PMID 9222367Read ↗

Sequence heterogeneity of HTLV-I proviral DNA in the central nervous system of patients with HTLV-I-associated myelopathy.Semantic proximity Read ↗

Sequence comparisons of HTLV-I from HAM/TSP patients and their asymptomatic spouses.Semantic proximity Read ↗

Analyses of HTLV-1 sequences suggest interaction between ORF-I mutations and HAM/TSP outcome.Semantic proximity Read ↗

Mutation rates in LTR of HTLV-1 in HAM/TSP patients and the carriers are similarly high to Tax/Rex-coding sequence.Semantic proximity Read ↗

Nucleotide sequence analysis of a provirus derived from an individual with tropical spastic paraparesis.Semantic proximity Read ↗

Human T cell leukemia virus type I (HTLV-I) molecular genotypes and disease outcome.Semantic proximity Read ↗

Sequence variants of human T-cell lymphotropic virus type I from patients with tropical spastic paraparesis and adult T-cell leukemia do not distinguish neurological from leukemic isolates.Semantic proximity Read ↗

Nucleotide sequence analysis of human T-cell lymphotropic virus type I pX and LTR regions from patients with sicca syndrome.Semantic proximity Read ↗

TREX1 531C>T Polymorphism is Associated with High Proviral Load Levels in HTLV-1-Infected Persons.Semantic proximity Read ↗

Limited sequence divergence of HTLV-I of Indian HAM/TSP patients from a prototype Japanese isolate.Semantic proximity Read ↗

Predominant recognition of human T cell leukemia virus type I (HTLV-I) pX gene products by human CD8+ cytotoxic T cells directed against HTLV-I-infected cells.Semantic proximity Read ↗

Serum concentration and genetic polymorphism in the 5'-untraslated region of VEGF is not associated with susceptibility to HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) in HTLV-I infected individuals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.