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TREX1 531C>T Polymorphism is Associated with High Proviral Load Levels in HTLV-1-Infected Persons.

Viruses - 19 Dec 2019

Silva Denis de Castro, Amoras Ednelza da Silva Graça, Moura Tuane Carolina Ferreira, Lopes Felipe Teixeira, Gomes Samara Tatielle Monteiro, Costa Carlos A da, Sousa Maísa Silva, Ishak Ricardo, Vallinoto Antonio Carlos Rosário, Queiroz Maria Alice Freitas

Abstract excerpt

Human T-lymphotropic virus type 1 (HTLV-1) deregulates the immune system and cell cycle, resulting in loss of immune tolerance and disease, including HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Three prime repair exonuclease 1 (TREX1) maintains innate immune tolerance of the host and host-cell permissiveness to retroviral infections. TREX1 polymorphisms may influence the course of...

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Identifiers

PMID: 31861565
DOI: 10.3390/v12010007
PMCID: PMC7019804

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Source receipt: pubmed, retrieved 7 Sept 2026.

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