Article
Predominant recognition of human T cell leukemia virus type I (HTLV-I) pX gene products by human CD8+ cytotoxic T cells directed against HTLV-I-infected cells.
International immunology - 1 Aug 1991
Kannagi M, Harada S, Maruyama I, Inoko H, Igarashi H, Kuwashima G, Sato S, Morita M, Kidokoro M, Sugimoto M
Abstract excerpt
We established long-term cell lines of cytotoxic T lymphocytes (CTL) specific for human T cell leukemia virus type I (HTLV-I) from peripheral blood lymphocytes (PBL) of a patient with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), an HTLV-I-carrier with Sjögren syndrome, and an asymptomatic HTLV-I-carrier, by repeated stimulation with autologous HTLV-I-infected T cells in vitro. CTL derived...
Topics
- Adult
- B-Lymphocytes
- CD8 Antigens
- Cell Line
- Female
- Gene Products, tax
- HLA-A2 Antigen
- HTLV-I Infections
- Humans
- Paraparesis, Tropical Spastic
- Phenotype
