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Article

Caenorhabditis elegans levamisole resistance genes lev-1, unc-29, and unc-38 encode functional nicotinic acetylcholine receptor subunits.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Aug 1997

Fleming J T, Squire M D, Barnes T M, Tornoe C, Matsuda K, Ahnn J, Fire A, Sulston J E, Barnard E A, Sattelle D B, Lewis J A

Abstract excerpt

We show that three of the eleven genes of the nematode Caenorhabditis elegans that mediate resistance to the nematocide levamisole and to other cholinergic agonists encode nicotinic acetylcholine receptor (nAChR) subunits. unc-38 encodes an alpha subunit while lev-1 and unc-29 encode non-alpha subunits. The nematode nAChR subunits show conservation of many mammalian nAChR sequence features, implying an ancient...

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PMID: 9221782
PMCID: PMC6573193

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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