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Article

Contribution of subunits to Caenorhabditis elegans levamisole-sensitive nicotinic receptor function.

Molecular pharmacology - 1 Sept 2012

Hernando Guillermina, Bergé Ignacio, Rayes Diego, Bouzat Cecilia

Abstract excerpt

Caenorhabditis elegans muscle contains seven different nicotinic receptor (AChR) subunits, five of which have been shown to be components of adult levamisole-sensitive AChRs (L-AChRs). To elucidate the reason for such subunit diversity, we explore their functional roles in larva 1 (L1) muscle cells. Single-channel and macroscopic current recordings reveal that the α-type LEV-8 subunit is a component of native L1...

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PMID: 22734069
DOI: 10.1124/mol.112.079962

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ACR

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