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Article

Molecular basis of the differential sensitivity of nematode and mammalian muscle to the anthelmintic agent levamisole.

The Journal of biological chemistry - 27 Aug 2004

Rayes Diego, De Rosa María José, Bartos Mariana, Bouzat Cecilia

Abstract excerpt

Levamisole is an anthelmintic agent that exerts its therapeutic effect by acting as a full agonist of the nicotinic receptor (AChR) of nematode muscle. Its action at the mammalian muscle AChR has not been elucidated to date despite its wide use as an anthelmintic in humans and cattle. By single c...

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Identifiers

PMID: 15201284
DOI: 10.1074/jbc.M403096200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15201284-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Molecular basis of the differential sensitivity of nematode and mammalian muscle to the anthelmintic agent levamisole.PMID 15201284Read ↗

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The Caenorhabditis elegans unc-63 gene encodes a levamisole-sensitive nicotinic acetylcholine receptor alpha subunit.Semantic proximity Read ↗

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