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Eight genes are required for functional reconstitution of the <i>Caenorhabditis elegans</i> levamisole-sensitive acetylcholine receptor

19 Nov 2008

Abstract excerpt

Levamisole-sensitive acetylcholine receptors (L-AChRs) are ligand-gated ion channels that mediate excitatory neurotransmission at the neuromuscular junctions of nematodes. They constitute a major drug target for anthelminthic treatments because they can be activated by nematode-specific cholinergic agonists such as levamisole. Genetic screens conducted in Caenorhabditis elegans for resistance to levamisole...

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PMID: 19020092
DOI: 10.1073/pnas.0806933105

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Eight genes are required for functional reconstitution of the <i>Caenorhabditis elegans</i> levamisole-sensitive acetylcholine receptorPMID 19020092Read ↗

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