Article
Alpha7 mutants mimicking atypical motifs (YxxCC of loop-C, and E to H at -1' in TM2) in the C. elegans LEV-8 subunit affect nicotinic acetylcholine receptor function.
Invertebrate neuroscience : IN - 1 Jun 2006
Towers Paula R, Pym Luanda, Yokota Maiko, Matsuda Kazuhiko, Sattelle David B
Abstract excerpt
The ACR-8-like group of C. elegans nicotinic acetylcholine receptor (nAChR) subunits contain unusual motifs in the ACh binding site and in the -1' position of transmembrane region two (TM2). Using site-directed mutagenesis (SDM) we have introduced these motifs into chicken alpha7 as it has not been possible to express C. elegans nAChR in vitro. Oocytes expressing alpha7 with the C. elegans binding motif show a...
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