Article
Protein engineering of protein kinase A catalytic subunits results in the acquisition of novel inhibitor sensitivity.
The Journal of biological chemistry - 9 Aug 2002
Niswender Colleen M, Ishihara R Wesley, Judge Luke M, Zhang Chao, Shokat Kevan M, McKnight G Stanley
Abstract excerpt
Analysis of the role of specific protein kinases in signal transduction networks has relied heavily on ATP analog inhibitors. Currently used agents, however, often do not distinguish between kinase family members. Genetic approaches can also be used to inactivate a specific kinase, but these techniques do not afford the rapid kinetics possible with pharmacological inhibitors. To circumvent this problem,...
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