Article
Lack of phospholipase A2 mutations in neuroblastoma, melanoma and colon-cancer cell lines.
International journal of cancer - 17 Jul 1997
Haluska F G, Thiele C, Goldstein A, Tsao H, Benoit E P, Housman D
Abstract excerpt
A candidate murine tumor-suppressor gene, Mom1, has been identified as the secretory phospholipase A2 (GDB nomenclature: PLA2G2A) gene. Evidence suggests that PLA2G2A functions as a tumor-suppressor because mice lacking PLA2G2A expression demonstrate increased colonic polyposis. The human homologue of PLA2G2A has been mapped to chromosome 1p36, a region frequently implicated in the pathogenesis of neuroblastoma,...
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