Article
Mutations in the neurofibromatosis 1 gene in sporadic malignant melanoma cell lines.
Nature genetics - 1 Feb 1993
Andersen L B, Fountain J W, Gutmann D H, Tarlé S A, Glover T W, Dracopoli N C, Housman D E, Collins F S
Abstract excerpt
Neurofibromatosis type 1 (NF1) is a common autosomal dominant disorder characterized by progressive and variable involvement of tissues predominantly derived from the neural crest and a predisposition toward malignancies. The NF1 gene encodes neurofibromin, a GTPase-activating protein containing a GAP-related domain (NF1-GRD) that is capable of down-regulating ras by stimulating its intrinsic GTPase activity. We...
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