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Article

Variants at the secretory phospholipase A2 (PLA2G2A) locus: analysis of associations with familial adenomatous polyposis and sporadic colorectal tumours.

Annals of human genetics - 1 Sept 1996

Tomlinson I P, Beck N E, Neale K, Bodmer W F

Abstract excerpt

The Min mouse is a model for human familial adenomatous polyposis (FAP), an autosomal dominant disease characterised by multiple adenomatous gastrointestinal polyps. The severity of the Min phenotype is modified by a locus (Mom1) on mouse chromosome 4, at a position syntenic with human chromosome 1p35-p36. The secretory phospholipase A2 (Pla2s) gene is a candidate for this modifier locus and there is evidence...

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Source

Identifiers

PMID: 8912789
DOI: 10.1111/j.1469-1809.1996.tb00434.x

Genes

FAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Variants at the secretory phospholipase A2 (PLA2G2A) locus: analysis of associations with familial adenomatous polyposis and sporadic colorectal tumours.PMID 8912789Read ↗

Three secretory phospholipase A(2) genes that map to human chromosome 1P35-36 are not mutated in individuals with attenuated adenomatous polyposis coli.Semantic proximity Read ↗

A modifying locus for familial adenomatous polyposis may be present on chromosome 1p35-p36.Semantic proximity Read ↗

Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis.Semantic proximity Read ↗

The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia.Semantic proximity Read ↗

Secretory phospholipase A2 does not appear to be associated with phenotypic variation in familial adenomatous polyposis.Semantic proximity Read ↗

Explaining variation in familial adenomatous polyposis: relationship between genotype and phenotype and evidence for modifier genes.Semantic proximity Read ↗

Genetic mapping of novel modifiers for ApcMin induced intestinal polyps’ development using the genetic architecture power of the collaborative cross miceSemantic proximity Read ↗

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Identification of a modifier gene locus on chromosome 1p35-36 in familial adenomatous polyposis.Semantic proximity Read ↗

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene.Semantic proximity Read ↗

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Expression analysis of the group IIA secretory phospholipase A(2) in mice with differential susceptibility to azoxymethane-induced colon tumorigenesis.Semantic proximity Read ↗

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