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Expression of secretory phospholipase A2 in colon tumor cells potentiates tumor growth

7 Nov 2006

Abstract excerpt

Secretory phospholipase A2 (sPLA2-IIA) has been shown to attenuate intestinal tumorigenesis in Apc(Min) mice, demonstrating that it is a tumor modifier. To further explore the actions of sPLA2-IIA in tumorigenesis, sPLA2-IIA was overexpressed in two cell lines where it is normally absent, the murine colon tumor cell line AJ02nm0, and human colon carcinoma cell line HCT-116. Two allelic variants of sPLA2-IIA were...

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PMID: 17091473
DOI: 10.1002/mc.20271

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