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Article

A mouse B16 melanoma mutant deficient in glycolipids.

Proceedings of the National Academy of Sciences of the United States of America - 29 Mar 1994

Ichikawa S, Nakajo N, Sakiyama H, Hirabayashi Y

Abstract excerpt

Mouse B16 melanoma cell line, GM-95 (formerly designated as MEC-4), deficient in sialyllactosylceramide was examined for its primary defect. Glycolipids from the mutant cells were analyzed by high-performance TLC. No glycolipid was detected in GM-95 cells, even when total lipid from 10(7) cells was analyzed. In contrast, the content of ceramide, a precursor lipid molecule of glycolipids, was normal. Thus, the...

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Identifiers

PMID: 8146177
DOI: 10.1073/pnas.91.7.2703
PMCID: PMC43438

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