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Article

Secretory phospholipase A2 does not appear to be associated with phenotypic variation in familial adenomatous polyposis.

Human genetics - 1 Sept 1996

Dobbie Z, Müller H, Scott R J

Abstract excerpt

Recent studies in mice have provided strong evidence for a modifier gene that is capable of effecting the expression of the mouse equivalent of familial adenomatous polyposis (FAP). A candidate gene has been proposed, namely secretory phospholipase A2 (sPLA2). Increased tumor number in mice was correlated with low levels of sPLA2 expression and the presence of truncating mutations within the sPLA2 gene. In an...

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Identifiers

PMID: 8707313
DOI: 10.1007/s004390050226

Genes

FAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Secretory phospholipase A2 does not appear to be associated with phenotypic variation in familial adenomatous polyposis.PMID 8707313Read ↗

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On the diversity of secreted phospholipases A(2). Cloning, tissue distribution, and functional expression of two novel mouse group II enzymes.Semantic proximity Read ↗

Deficiency in sPLA(2) does not affect HDL levels or atherosclerosis in mice.Semantic proximity Read ↗

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