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Article

Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma.

Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1990

Tsuda H, Zhang W D, Shimosato Y, Yokota J, Terada M, Sugimura T, Miyamura T, Hirohashi S

Abstract excerpt

Loss of heterozygosity on chromosome 16 is a common genetic alteration in human hepatocellular carcinoma (HCC). To clarify the pathogenetic significance of allele loss on chromosome 16, we performed restriction fragment length polymorphism analysis of 70 surgically resected tumors by using 15 polymorphic DNA markers for chromosome 16. Loss of heterozygosity on chromosome 16 was detected in 36 (52%) of 69...

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Identifiers

PMID: 2168560
DOI: 10.1073/pnas.87.17.6791
PMCID: PMC54623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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