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Article

Genetic evidence that heparin-like glycosaminoglycans are involved in wingless signaling.

Development (Cambridge, England) - 1 Jul 1997

Binari R C, Staveley B E, Johnson W A, Godavarti R, Sasisekharan R, Manoukian A S

Abstract excerpt

We have identified the Drosophila UDP-glucose dehydrogenase gene as being involved in wingless signaling. Mutations in this gene, called kiwi, generate a phenotype identical to that of wingless. UDP-glucose dehydrogenase is required for the biosynthesis of UDP-glucuronate, which in turn is utilized in the biosynthesis of glycosaminoglycans. By rescuing the kiwi phenotype with both UDP-glucuronate and the...

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Identifiers

PMID: 9217004
DOI: 10.1242/dev.124.13.2623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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