Article
Functional analysis of proteoglycan galactosyltransferase II RNA interference mutant flies.
The Journal of biological chemistry - 7 Mar 2008
Ueyama Morio, Takemae Hitoshi, Ohmae Yoshiko, Yoshida Hideki, Toyoda Hidenao, Ueda Ryu, Nishihara Shoko
Abstract excerpt
Heparan sulfate proteoglycan plays an important role in developmental processes by modulating the distribution and stability of the morphogens Wingless, Hedgehog, and Decapentaplegic. Heparan and chondroitin sulfates share a common linkage tetrasaccharide structure, GlcAbeta1,3Galbeta1,3Galbeta1,4Xylbeta-O-Ser. In the present study, we identified Drosophila proteoglycan galactosyltransferase II (dbeta3GalTII),...
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