Article
Essential role of glycosaminoglycans in Fgf signaling during mouse gastrulation.
Cell - 19 Sept 2003
García-García María J, Anderson Kathryn V
Abstract excerpt
In vitro studies have suggested that proteoglycans facilitate signaling by mammalian growth factors, but genetic evidence supporting this role has been lacking. Here, we characterize the ENU-induced mutation lazy mesoderm (lzme), which disrupts the single mouse gene encoding UDP-glucose dehydrogenase (Ugdh), an enzyme required for the synthesis of the glycosaminoglycan (GAG) side chains of proteoglycans. lzme...
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