Article
Functional genomic analysis of the Wnt-wingless signaling pathway.
Science (New York, N.Y.) - 6 May 2005
DasGupta Ramanuj, Kaykas Ajamete, Moon Randall T, Perrimon Norbert
Abstract excerpt
The Wnt-Wingless (Wg) pathway is one of a core set of evolutionarily conserved signaling pathways that regulates many aspects of metazoan development. Aberrant Wnt signaling has been linked to human disease. In the present study, we used a genomewide RNA interference (RNAi) screen in Drosophila cells to screen for regulators of the Wnt pathway. We identified 238 potential regulators, which include known pathway...
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